Chicago Sun-Times: Parkinson's drug blamed for compulsive gambling

Joe Neglia was a retired government intelligence worker with Parkinson's disease when he suddenly developed what he calls a gambling habit from hell.

After losing thousands of dollars playing slot machines near his California home several times a day for nearly two years, Neglia came across a report linking a popular Parkinson's drug he used with compulsive gambling.

"I thought, 'Oh my God, this must be it,"' he said. Three days after stopping the drug, Mirapex, "all desire to gamble just went away completely."

'Enough for us to be cautious'

A Mayo Clinic study published Monday in July's Archives of Neurology describes 11 other Parkinson's patients who developed the unusual problem while taking Mirapex or similar drugs between 2002 and 2004. Doctors have since identified 14 additional Mayo patients with the problem, said lead author Dr. M. Leann Dodd, a Mayo psychiatrist.

"It's certainly enough for us to be cautious as we are using it," Dodd said.

Dr. Leo Verhagen, a Parkinson's specialist at Chicago's Rush University Medical Center who was not involved in the study, says he and some colleagues all have a few patients who developed compulsive gambling while taking Mirapex, a drug that relieves tremors and stiffness. The behavior usually disappears when the drug dose is lowered, Verhagen said.